A dual-caged resorufin probe for rapid screening of infections resistant to lactam antibiotics
Jinghang Xie, Ran Mu, Mingxi Fang, Yunfeng Cheng, Fiona Senchyna, Ángel Moreno, Niaz Banaei, Jianghong Rao
Abstract
This work reports a dual-caged fluorogenic probe and its demonstration for rapid and sensitive screening of as low as 1000 clinically isolated β-lactamase-expressing bacteria per milliliter urine samples within 2 hours.
Topics & Concepts
AntibioticsLactamMicrobiologyChemistryBeta-lactamMedicineCombinatorial chemistryStereochemistryBiologyAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyAntimicrobial Resistance in Staphylococcus