Mutant p53 Gain of Function: Why Many See It, Why Some Do Not
Guillermina Lozano, Carol Prives, Kanaga Sabapathy
Abstract
Mutations in the TP53 tumor-suppressor gene in human cancer are unique in that 60% to 70% are of the missense variety, resulting in a full-length protein that is often highly expressed in patients' tumors. These missense mutant proteins often exhibit pro-oncogenic activities (referred to as gain of function) in mouse models and human cell lines and correlate with poor cancer prognosis in some cases.
Topics & Concepts
Missense mutationGain of functionMutantSuppressorGeneBiologyCancerP53 proteinCancer researchFunction (biology)Loss functionGeneticsMutant proteinMutationPhenotypeCancer-related Molecular PathwaysCancer Genomics and DiagnosticsMolecular Biology Techniques and Applications