A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells
Yawara Kawano, Takayuki Sasano, Yuichiro Arima, Saki Kushima, Kenichi Tsujita, Masao Matsuoka, Hiroyuki Hata
Topics & Concepts
GlycolysisApoptosisBortezomibIntracellularProgrammed cell deathPyruvate kinaseCancer cellBiochemistryMetabolitePyruvate dehydrogenase kinaseProteasome inhibitorKinaseProteasomeCell biologyChemistryPyruvate dehydrogenase complexCancer researchMetabolismBiologyMultiple myelomaEnzymeCancerGeneticsImmunologyCancer therapeutics and mechanismsBiochemical and Molecular ResearchEnzyme function and inhibition