Mouse Lung Structure and Function after Long-Term Exposure to an Atmospheric Carbon Dioxide Level Predicted by Climate Change Modeling
Alexander N. Larcombe, Melissa G. Papini, Emily K Chivers, Luke J. Berry, Robyn Lucas, Caitlin S. Wyrwoll
Abstract
BACKGROUND: experienced today), especially when exposures extend from preconception to adulthood, have not been thoroughly studied. OBJECTIVES: from preconception to adulthood using a mouse model. METHODS: and early life periods, until 3 months of age, at which point we assessed respiratory function using the forced oscillation technique, and lung structure. RESULTS: . DISCUSSION: can impact respiratory function in the mouse. https://doi.org/10.1289/EHP7305.
Topics & Concepts
Respiratory systemLungPhysiologyCarbon dioxideIn uteroInhalation exposureLung functionRespirationMedicineRespiratory physiologyCarbon dioxide in Earth's atmosphereAnimal scienceBiologyInternal medicineToxicityPregnancyEcologyAnatomyFetusGeneticsClimate Change and Health ImpactsAir Quality and Health ImpactsChronic Obstructive Pulmonary Disease (COPD) Research