A PorX/PorY and σ <sup>P</sup> Feedforward Regulatory Loop Controls Gene Expression Essential for Porphyromonas gingivalis Virulence
Chizhou Jiang, Dezhi Yang, Tangsiyuan Hua, Zichun Hua, Wei Kong, Yixin Shi
Abstract
The anaerobic bacterium Porphyromonas gingivalis is not only the major etiologic agent for chronic periodontitis, but also prevalent in some common noncommunicable diseases such as cardiovascular disease, Alzheimer's disease, and rheumatoid arthritis. We present genetic, biochemical, and biological results to demonstrate that the PorX/PorY two-component system and sigma factor σ P build a specific regulatory network to coordinately control transcription of the genes encoding the type IX secretion system, and perhaps also other virulence factors.
Topics & Concepts
Porphyromonas gingivalisPromoterBiologyTranscription (linguistics)General transcription factorSigma factorRNA polymeraseGeneMolecular biologyTranscription factorRepressorGene expressionCell biologyGeneticsRNALinguisticsBacteriaPhilosophyOral microbiology and periodontitis researchBacterial biofilms and quorum sensingBacterial Genetics and Biotechnology