Potential binding modes of the gut bacterial metabolite, 5-hydroxyindole, to the intestinal L-type calcium channels and its impact on the microbiota in rats
Barbora Waclawiková, Paulo C. T. Souza, Markus Schwalbe, Constantinos G. Neochoritis, Warner Hoornenborg, Sieger A. Nelemans, Siewert J. Marrink, Sahar El Aidy
Abstract
, 5-hydroxyindole stood as the most potent enhancer of the intestinal contractility. Overall, the present findings imply a potential role of microbiota-derived metabolites as candidate therapeutics for targeted treatment of slow intestinal motility-related disorders including constipation.
Topics & Concepts
BiologyMetaboliteGut floraCalciumMicrobiologyBiochemistryInternal medicineMedicineGut microbiota and healthTryptophan and brain disordersNeuroendocrine regulation and behavior