CXCL9 and CXCL10 bring the heat to tumors
Robin Reschke, Thomas F. Gajewski
Abstract
CXCL9 and CXCL10 can be produced by antigen-presenting cells (dendritic cells or macrophages) and by tumor cells. Hoch et al. demonstrated that CXCL9 and CXCL10 co-localize with LAG3 + T cells expressing CCL4 or CXCL13 and contribute to the generation of a “hot” tumor microenvironment.
Topics & Concepts
CXCL9CXCL10ChemokineBiologyMedicineImmunologyInflammationImmunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersImmune cells in cancer