An aqueous olive leaf extract (OLE) ameliorates parameters of oxidative stress associated with lipid accumulation and induces lipophagy in human hepatic cells
Stefano Tacconi, S. Longo, Flora Guerra, C. Moliteni, Marzia Friuli, Adele Romano, Silvana Gaetani, Vito Michele Paradiso, Graziana Difonzo, Francesco Caponio, Dario Domenico Lofrumento, Daniele Vergara, Cecilia Bucci, Luciana Dini, Anna Maria Giudetti
Abstract
accumulation and increased the activity of peroxide-detoxifying enzymes. OLE ameliorated mitochondrial membrane potential, and hepatic parameters by restoring the expression of enzymes involved in insulin signaling and lipid metabolism. Electron microscopy revealed an increased autophagosome formation in both FFA- and FFA + OLE-treated cells. The study of the autophagic pathway indicated OLE's probable role in activating lipophagy.
Topics & Concepts
Oxidative stressChemistryAqueous solutionLipid dropletOlive oilBiochemistryFood scienceCell biologyBiologyOrganic chemistryEdible Oils Quality and AnalysisPhytochemicals and Antioxidant ActivitiesCholesterol and Lipid Metabolism