Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE<sup>-/-</sup> mice with minimal side effects
Liang Zhang, Chen Wang, Wei Hu, Te Bu, Wenqi Sun, Tian Zhou, Shuo Qiu, Mengying Wei, Helin Xing, Zhelong Li, Guodong Yang, Lijun Yuan
Abstract
mRNA and the BAX activator BTSA1, efficiently induced apoptosis in recipient senescent cells in atherosclerotic plaques. This strategy represents a promising treatment approach for AS and other age-related diseases.
Topics & Concepts
ApoptosisActivator (genetics)MicrovesiclesCell biologyApolipoprotein EChemistryCancer researchBiologyMedicinePathologymicroRNABiochemistryGeneDiseaseExtracellular vesicles in diseaseMicroRNA in disease regulationPhagocytosis and Immune Regulation