Design, synthesis and anti-inflammatory evaluation of aloe-emodin derivatives as potential modulators of Akt, NF-κB and JNK signaling pathways
Hai Shang, Jing Guo, Pengtao Wang, Lingyu Li, Yu Tian, Xiaoxue Li, Zhongmei Zou
Topics & Concepts
ChemistryNitric oxideNF-κBProtein kinase BEmodinPharmacologySignal transductionInhibitory postsynaptic potentialAnti-inflammatoryAloe emodinProinflammatory cytokineIC50Nitric oxide synthaseInflammationStructure–activity relationshipBiochemistryIn vitroImmunologyEndocrinologyBiologyOrganic chemistryPhytochemistry and biological activity of medicinal plantsBiological and pharmacological studies of plantsGinseng Biological Effects and Applications