Differential <i>In Vitro</i> Activities of Individual Drugs and Bedaquiline-Rifabutin Combinations against Actively Multiplying and Nutrient-Starved Mycobacterium abscessus
Jin Lee, Nicole C. Ammerman, Anusha Agarwal, Maram Naji, Si-Yang Li, Eric L. Nuermberger
Abstract
Current treatment options for lung disease caused by Mycobacterium abscessus complex infections have limited effectiveness. To maximize the use of existing antibacterials and to help inform regimen design for treatment, we assessed the in vitro bactericidal activity of single drugs against actively multiplying and net nonreplicating M. abscessus populations in nutrient-rich and nutrient-starvation conditions, respectively. As single drugs, bedaquiline and rifabutin exerted bactericidal activity only against nutrient-starved and actively growing M. abscessus , respectively.
Topics & Concepts
RifabutinBedaquilineMicrobiologyMycobacterium abscessusMycobacteriumAntibioticsClarithromycinIn vitroBiologyMedicinePharmacologyBacteriaMycobacterium tuberculosisTuberculosisBiochemistryPathologyGeneticsMycobacterium research and diagnosisQuinazolinone synthesis and applicationsTuberculosis Research and Epidemiology