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Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

Benjamin Chun‐Kit Tong, Aston Jiaxi Wu, Shiying Huang, Rui Dong, Sandeep Malampati, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Cheng-Fu Su, Jia Liu, Ju‐Xian Song, Jiahong Lu, Jieqiong Tan, Weidong Pan, Min Li, King‐Ho Cheung

2021Autophagy49 citationsDOIOpen Access PDF

Abstract

ABBREVIATIONS: -ATPase.

Topics & Concepts

PresenilinAutophagyLysosomeBiologySequestosome 1Amyloid betaCell biologyAmyloid precursor proteinAlzheimer's diseasePSEN1EndocrinologyInternal medicineBiochemistryMedicineDiseasePeptideEnzymeApoptosisCalcium signaling and nucleotide metabolismAutophagy in Disease and TherapyPlant Molecular Biology Research
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease | Litcius