Pristine gelatin incorporation as a strategy to enhance the biofunctionality of poly(vinyl alcohol)-based hydrogels for tissue engineering applications
Alessia Longoni, Gretel Major, Shaoyuan Jiang, Brooke L. Farrugia, David Kieser, Tim B. F. Woodfield, Jelena Rnjak‐Kovacina, Khoon S. Lim
Abstract
cell-biomaterial interaction. Nevertheless, the presence of gelatin or VEGF was necessary to enhance blood vessel recruitment and infiltration, although no significant difference was observed between these two biological molecules. Overall, this study highlights the potential of gelatin as a standalone pro-angiogenic cue to enhance biofunctionality of synthetic hydrogels and provides promise for their use in a variety of TERM applications.
Topics & Concepts
Vinyl alcoholSelf-healing hydrogelsGelatinTissue engineeringChemistryChemical engineeringPolymer sciencePolymer chemistryPolymerBiomedical engineeringOrganic chemistryEngineering3D Printing in Biomedical ResearchElectrospun Nanofibers in Biomedical ApplicationsHydrogels: synthesis, properties, applications