Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations
Abigail Leinroth, Anthony J. Mirando, Douglas Rouse, Yoshihiko Kobayahsi, Purushothama Rao Tata, Helen Rueckert, Yihan Liao, Jason T. Long, Joe V. Chakkalakal, Matthew J. Hilton
Abstract
non-myogenic muscle-resident mesenchymal cell populations that fit within a bipartite differentiation trajectory from a common progenitor. One branch of the trajectory gives rise to two populations of immune-responsive mesenchymal cells with strong adipogenic potential and the capability to respond to acute and chronic muscle injury, whereas the alternative branch contains two cell populations with limited adipogenic capacity and inherent mineralizing capabilities; one of the populations displays a unique neuromuscular junction association and an ability to respond to nerve injury.