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Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells

Jiadi Lv, Si Tian, Dianheng Wang, Chaoqi Zhang, Yabo Zhou, Jin Yu, Yishen Jiang, Dongxiao Wu, Li Zhou, Zhenfeng Wang, Nannan Zhou, Jie Chen, Keke Wei, Huafeng Zhang, Jingwei Ma, Ke Tang, Xuetao Cao, Bo Huang

2025Immunity11 citationsDOI

Topics & Concepts

SOX2BiologyCell biologyStem cellHomeobox protein NANOGChimeric antigen receptorCancer stem cellCellular differentiationCancer researchImmunologyT cellEmbryonic stem cellInduced pluripotent stem cellImmune systemGeneBiochemistryCAR-T cell therapy researchImmunotherapy and Immune ResponsesViral Infectious Diseases and Gene Expression in Insects
Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells | Litcius