The injury response to DNA damage in live tumor cells promotes antitumor immunity
Ganapathy Sriram, Lauren E. Milling, Jung-Kuei Chen, Yi Wen Kong, Brian A. Joughin, Wuhbet Abraham, Susanne Swartwout, Erika D. Handly, Darrell J. Irvine, Michael B. Yaffe
Abstract
mice and in mice in which the DNA-damaging drug was injected directly into the tumor, due to DNA damage in the immune cells. The combination treatment induced complete tumor regression in a subset of mice that were then able to reject tumor rechallenge, indicating that the injured cell adjuvant treatment induced durable antitumor immunological memory. These results provide a strategy for enhancing the efficacy of immune checkpoint inhibition in tumor types that do not respond to this treatment modality by itself.
Topics & Concepts
DNA damageEx vivoIn vivoImmunityAdjuvantCancer researchImmunologyImmune systemDNABiologyCell biologyGeneticsImmunotherapy and Immune ResponsesImmune Cell Function and InteractionCell death mechanisms and regulation