Accelerating CEST MRI in the mouse brain at 9.4 T by exploiting sparsity in the <i>Z</i>‐spectrum domain
Grzegorz Kwiatkowski, Sebastian Kozerke
Abstract
PURPOSE: Chemical exchange saturation transfer (CEST) is an MR contrast modality offering an enhanced sensitivity for the detection of dilute metabolites with exchangeable protons. Quantitative analysis requires the acquisition of a number of images (usually between 20 and 50 RF offsets) per Z-spectrum, leading to long acquisition times of the order of 5-40 min in practice. In this work, we explore the possibility of employing sparsity in the Z-spectrum domain (irradiation offset dimension) to provide an accelerated acquisition scheme without compromising the quality of reconstructed CEST spectra. METHOD AND THEORY: Ex vivo and in vivo data were acquired on an experimental, small animal 9.4 T system. Three different reconstruction methods were tested: k-Z SPARSE, k-Z SLR and k-Z principal component analysis (PCA) using retrospective undersampling with net acceleration factors R = 2, 3, 5. The quality of the reconstructed data was compared with respect to CEST spectra and full magnetization transfer ratio (MTR) asymmetry maps. RESULTS: In both phantom and in vivo data, CEST spectra and the resulting MTR asymmetry maps were reconstructed without significant deterioration in data quality. For a low acceleration factor (R = 2, 3) all applied methods resulted in similar data quality, while for high acceleration factor (R = 5) only k-Z PCA and k-Z SLR could be used. Loss in spatial resolution was observed in reconstruction with k-Z PCA for all acceleration factors. An example of prospective undersampling with acceleration factor R = 3 and k-Z PCA reconstruction demonstrates improved CEST maps when compared with fully sampled data acquisition with either three times longer scan duration or threefold prolonged acquisition window per frequency offset. CONCLUSION: The acquisition time of CEST spectra can be significantly accelerated by exploiting the sparsity of the Z-domain. For prospective and retrospective analysis using k-Z PCA, an acceleration factor of up to R = 3 can be used without significant loss in data quality.