Progress in 11β-HSD1 inhibitors for the treatment of metabolic diseases: A comprehensive guide to their chemical structure diversity in drug development
Chuanxin Zhong, Wang Shengzheng, Lei Dang, Duoli Xie, Jin Liu, Ren Fuzeng, Lu A, Ge Zhang
Topics & Concepts
Drug discoveryType 2 Diabetes Mellitus11β-hydroxysteroid dehydrogenase type 1ChemistryComputational biologyEnzymeDrugDrug developmentPharmacologyDiabetes mellitusBiochemistryDehydrogenaseBiologyEndocrinologyHormonal Regulation and HypertensionCoenzyme Q10 studies and effectsEstrogen and related hormone effects