Design, synthesis, in vitro antimicrobial evaluation and molecular docking studies of indol-2-one tagged with morpholinosulfonyl moiety as DNA gyrase inhibitors
Mohamed A. Salem, Ahmed Ragab, Abeer El-Khalafawy, Abeer H. Makhlouf, Ahmed A. Askar, Yousry A. Ammar
Topics & Concepts
DNA gyraseChemistryNorfloxacinAntimicrobialHydrazideMoietyDocking (animal)CiprofloxacinStereochemistryDNAAntibacterial activityBiochemistryCombinatorial chemistryBacteriaAntibioticsEscherichia coliOrganic chemistryGeneBiologyGeneticsNursingMedicineSynthesis and biological activitySynthesis and Biological EvaluationBioactive Compounds and Antitumor Agents