Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor
Rajesh Kumar, Michael J. Karmilowicz, Dylan Burke, Michael P. Burns, Leslie Clark, Christina G. Connor, Eric M. Cordi, Nga M., Kevin M. Doyle, Steve Hoagland, Chad A. Lewis, David Mangan, Carlos A. Martínez, Emma L. McInturff, Kevin Meldrum, Robert S. Pearson, Jeremy Steflik, Anil Rane, John D. Weaver
Topics & Concepts
Reductive aminationImineChemistryCombinatorial chemistryMethylamineAminationAmine gas treatingOrganic chemistryCatalysisEnzyme Catalysis and ImmobilizationBiochemical and Molecular ResearchMicrobial Metabolic Engineering and Bioproduction