Probing the Mechanism of Hepatotoxicity of Hexabromocyclododecanes through Toxicological Network Analysis
Weina Dai, Tiantian Tang, Zhenghua Dai, Da Shi, Lingyun Mo, Yonghong Zhang
Abstract
< 0.001) involved in oxidative stress, cellular immunity, and proliferation, and the accuracy of hepatotoxicity prediction of HBCD was 0.7095 ± 0.0193 and the recall score was 0.8355 ± 0.0352. HBCD mainly affects the core disease module genes to mediate the adenosine monophosphate-activated kinase, p38MAPK, PI3K/Akt, and TNFα pathways to regulate the immune reaction and inflammation. HBCD also induces the secretion of IL6 and STAT3 to lead hepatotoxicity by regulating NR3C1. This approach is transferable to other toxicity research studies of environmental pollutants.
Topics & Concepts
HexabromocyclododecaneGeneBiologyChemistryPharmacologyComputational biologyBiochemistryFire retardantOrganic chemistryComputational Drug Discovery MethodsGlutathione Transferases and PolymorphismsPharmacogenetics and Drug Metabolism