Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer
Wagdy M. Eldehna, Eslam Essam Mohammed, Ghada H. Al-Ansary, Emanuela Berrino, Mostafa M. Elbadawi, Tamer M. Ibrahim, Maiy Y. Jaballah, Sara T. Al‐Rashood, Faizah A. Binjubair, M. Salih Celik, Alessio Nocentini, Fawzy Elbarbry, Fikrettin Şahi̇n, Hatem A. Abdel‐Aziz, Claudiu T. Supuran, Mohamed Farès
Topics & Concepts
ChemistryCancer researchViability assayColorectal cancerCell growthApoptosisCell cultureAngiogenesisCarbonic anhydraseCancer cellCancerBiochemistryEnzymeBiologyInternal medicineMedicineGeneticsEnzyme function and inhibitionSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and Activities