A multifunctional divergent scaffold to access the formal syntheses of various sesquiterpenoids
Vera P. Demertzidou, Maria Kourgiantaki, Alexandros L. Zografos
Abstract
The development of a divergent scaffold able to access an array of diverse natural sesquiterpenoids is described. The route unifies the scope of previously reported plans of our group to allow the scalable synthesis of 8,12-furo and lactone sesquiterpenoid carbocyclic cores of elemanes, germacranes, guaianes, cadinanes, lindenanes and myliols. The formal syntheses of furogermenone, methyl-curdionolide, zedoarol, qweicurculactone, lindenene and sarcandralactone A are reported.
Topics & Concepts
ScaffoldChemistryScope (computer science)Formal synthesisCombinatorial chemistryStereochemistryComputer scienceProgramming languageSesquiterpenes and Asteraceae StudiesSynthetic Organic Chemistry MethodsTraditional and Medicinal Uses of Annonaceae