Porous Lanthanum‐Doped Manganese Oxide Nanoparticles for Enhanced Sonodynamic Cancer Therapy
Jinhao Zhou, Liyin Shi, Qiyu Liu, Haozhe Zhang, Xiaoqing Liu, Feng Han, Zhixing Guo, Xihong Lu, Jianwei Wang
Abstract
Abstract Metal oxides hold great promise as robust sonosensitizers for sonodynamic therapy (SDT). However, they usually suffer from limited production yield of reactive oxygen species (ROS) due to the fast recombination of ultrasound‐triggered electrons and holes. Herein, porous lanthanum (La)‐doped MnO 2 (LMO) nanoparticles are firstly developed as promising sonosensitizers in SDT. The strategic introduction of La dopants greatly promotes the separation efficiency of ultrasound‐triggered electrons and holes of MnO 2 , endowing them with significantly improved ROS yield. Consequently, the LMO with polyethylene glycol decoration exhibits good SDT activity toward breast cancer cells. This work highlights the doping strategy for the development of enhanced ROS production of metal oxide sonosensitizers for SDT.