Experience in the diagnosis and treatment of pneumonia caused by infection with Tropheryma whipplei: A case series
Zhixiong Fang, Qiong Liu, Wei Tang, Hongyin Yu, Min Zou, Haiming Zhang, Haiyan Xue, Sha Lin, Yi Pei, Jingwen Ai, Jun Chen
Abstract
(TW) is the root cause of Whipple's disease (WD), a rare infectious illness leading to multi-organ impairment. A prominent feature of WD is acute pneumonia, which can be exceedingly challenging to diagnose clinically due to the pathogen's surreptitious nature. However and significantly, with the advent of metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF), it offers clinicians a potent tool at their disposal to detect TW infections. The present study conducted a retrospective analysis of clinical data gleaned from five patients in Hunan Province in China. Findings in this study demonstrated the potential of BALF-mNGS in diagnosing pneumonia caused by TW infection.