The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation
Chuanhui Han, Victoria Godfrey, Zhida Liu, Yanfei Han, Longchao Liu, Hua Peng, Ralph R. Weichselbaum, Hasan Zaki, Yang-Xin Fu
Abstract
mice. IL-1 signaling in dendritic cells (DCs) promoted radiation-induced antitumor immunity by enhancing the cross-priming activity of DCs. Overall, we demonstrated that radiation-induced activation of the AIM2 and NLRP3 inflammasomes coordinate to induce some of the antitumor effects of radiation by triggering IL-1 signaling in DCs, leading to their activation and cross-priming.
Topics & Concepts
AIM2InflammasomeImmunityImmunologyCancer researchBiologyCell biologyInflammationImmune systemInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideEffects of Radiation Exposure