Synthetic Transformation of 2-{2-Fluoro[1,1′-biphenyl]-4-yl} Propanoic Acid into Hydrazide–Hydrazone Derivatives: <i>In Vitro</i> Urease Inhibition and <i>In Silico</i> Study
Sajjad Ahmad, Momin Khan, Muhammad Ishaq Ali Shah, Mahboob Ali, Aftab Alam, Muhammad Riaz, Khalid Mohammed Khan
Abstract
molecular modeling analysis was carried out to study the effect of substituents in synthesized derivatives on the binding interactions with the urease enzyme.
Topics & Concepts
ChemistryThioureaHydrazoneHydrazideFlurbiprofenUreaseStereochemistryIn silicoDocking (animal)EnzymeCombinatorial chemistryOrganic chemistryBiochemistryPharmacologyGeneMedicineNursingMicrobial Applications in Construction MaterialsEnzyme function and inhibitionSynthesis and biological activity