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A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner

Aude Sylvain, Natacha Stoehr, Fupeng Ma, Artiom Cernijenko, Martin Schröder, Maryam Khoshouei, Melanie Vogelsanger, Michel Schoenboerner, Ashley Burke, Pasupuleti Rao, Jonathan M. Solomon, Joshiawa Paulk, Lei Xu, Janet Dawson, Damien Bégué, Peggy Lefeuvre, Erik Ahrné, Andreas Hofmann, Callum J. Dickson, Philip Arabin, Alfred Zimmerlin, Michael Kiffe, Mirjam Froehlicher, Theresa Boersig, Azeddine Elhajouji, Murielle Brichet, Suchithra Menon, Shanming Liu, Matthias Mueller, Charles Wartchow, James A. Lin, Yamel Cardona Gloria, Sabine Dickhöfer, Alexander N.R. Weber, Tatjana Welzel, Jasmin Kuemmerle‐Deschner, Christopher J. Farady, Robert Pulz, Frédéric Bornancin, Dennis L. Buckley, Zuni I. Bassi

2025Cell chemical biology18 citationsDOI

Topics & Concepts

InflammasomePyrin domainCell biologyChemistryIn vitroBiologyReceptorBiochemistryUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysisinterferon and immune responses
A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner | Litcius