Ni-Catalyzed Regioselective Reductive 1,3-Dialkenylation of Alkenes
Laura M. Wickham, Roshan K. Dhungana, Ramesh Giri
Abstract
Dicarbofunctionalization is an important efficient synthetic technique for adding two chemical moieties across an alkene. Here, a novel method of reductive dicarbofunctionalization has been developed using a single alkenyl triflate as the electrophile, combined with an unactivated alkene. The reaction does not require an external auxiliary and proceeds with complete regioselectivity.
Topics & Concepts
RegioselectivityAlkeneElectrophileTrifluoromethanesulfonateCatalysisChemistryReductive eliminationCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis