Overexpression of ABCC1 and ABCG2 confers resistance to talazoparib, a poly (ADP-Ribose) polymerase inhibitor
Qiu‐Xu Teng, Zi‐Ning Lei, Jing‐Quan Wang, Yuqi Yang, Zhuo‐Xun Wu, Nikita Acharekar, Wei Zhang, Sabesan Yoganathan, Yihang Pan, John N.D. Wurpel, Zhe‐Sheng Chen, Shuo Fang
Topics & Concepts
Poly ADP ribose polymerasePARP inhibitorPolymeraseAbcg2ChemistryMolecular biologyBiologyBiochemistryEnzymeGeneTransporterATP-binding cassette transporterDrug Transport and Resistance MechanismsPARP inhibition in cancer therapyMetal complexes synthesis and properties