Upregulated Long Non-coding RNA Lnc-MRPL39-2:1 Induces the Growth and Invasion of Nasopharyngeal Carcinoma by Binding to HuR and Stabilizing β-Catenin mRNA
Yunhong Tian, Mei-Ling Ai, Chunshan Liu, Yuchao Wu, Muhammad Khurram Khan, Baiyao Wang, Huidong Long, Chunyue Huang, Jie Lin, Anan Xu, Rong Li, Bohong Cen, Wen‐Ze Qiu, Guofeng Xie, Yawei Yuan
Abstract
. Lnc-MRPL39-2:1 expression was also suppressed by microRNA (miR)-329. Thus, these findings indicate that lnc-MRPL39-2:1 is essential in NPC tumorigenesis and metastasis and highlight its potential as a prognostic marker and therapeutic target for NPC.
Topics & Concepts
Nasopharyngeal carcinomamicroRNABiologyLong non-coding RNACarcinogenesisCancer researchDownregulation and upregulationRNAMolecular biologyMALAT1MetastasisMessenger RNAImmunoprecipitationIn vivoCompeting endogenous RNACell cultureCancerGeneMedicineGeneticsRadiation therapyInternal medicineCancer-related molecular mechanisms researchRNA modifications and cancerCircular RNAs in diseases