Multiomics Investigation Revealing the Characteristics of HIV-1-Infected Cells In Vivo
Hirofumi Aso, Shumpei Nagaoka, Eiryo Kawakami, Jumpei Ito, Saiful Islam, Benjy J.Y. Tan, Shinji Nakaoka, Koichi Ashizaki, Katsuyuki Shiroguchi, Yutaka Suzuki, Yorifumi Satou, Yoshio Koyanagi, Kei Sato
Abstract
cells and a subpopulation with low expression of interferon-stimulated genes, which can contribute to efficient viral spread in vivo. Our findings describe multiple characteristics of HIV-1-producing cells in vivo, which could provide clues for the development of an HIV-1 cure.
Topics & Concepts
TranscriptomeBiologyIn vivoHaematopoiesisStem cellViral replicationVirologyInterferonLentivirusGenomeHuman immunodeficiency virus (HIV)GeneCell biologyComputational biologyVirusGene expressionGeneticsViral diseaseHIV Research and TreatmentImmune Cell Function and InteractionT-cell and B-cell Immunology