Discovery of hydrazide-based pyridazino[4,5-<i>b</i>]indole scaffold as a new phosphoinositide 3-kinase (PI3K) inhibitor for breast cancer therapy
Ahmed A. M. Sarhan, Ahmed T. A. Boraei, Assem Barakat, Mohamed S. Nafie
Abstract
The mono and dialkylation of pyridazino[4,5-<italic>b</italic>]indole with a set of alkylating agents were achieved. The synthesized pyridazino[4,5-<italic>b</italic>]indole hits have been evaluated and discovered as a new phosphoinositide 3-kinase (PI3K) inhibitor for breast cancer therapy.
Topics & Concepts
Indole testHydrazideChemistryPhosphoinositide 3-kinasePharmacologyPI3K/AKT/mTOR pathwayCancer therapyBreast cancerKinaseCancer researchCombinatorial chemistryCancerBiochemistryMedicineInternal medicineOrganic chemistrySignal transductionSynthesis and bioactivity of alkaloidsCancer therapeutics and mechanismsSynthesis and biological activity