Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma
Simona Citro, Alice Bellini, Alessandro Medda, Maria Elisa Sabatini, Marta Tagliabue, Francesco Chu, Susanna Chiocca
Abstract
P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Moreover, a clear relationship between the expression of ΔNp63α and the presence of high-risk HPV E6 and E7 oncoproteins has been delineated. Here we describe how ΔNp63α is mostly expressed in HPV-positive compared to HPV-negative head and neck cancer cell lines, with a very good correlation between ΔNp63α mRNA and protein levels.
Topics & Concepts
Human papilloma virusHead and neck cancerHead and neck squamous-cell carcinomaCancerCancer researchHead and neckBasal cellOncologyVirusMedicineBiologyPathologyInternal medicineCervical cancerVirologySurgeryCancer-related Molecular PathwaysRNA modifications and cancerMolecular Biology Techniques and Applications