Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis
Yang Lv, Wentao Tang, Yuqiu Xu, Wenju Chang, Zhiyuan Zhang, Lin Qi, Meiling Ji, Qingyang Feng, Guodong He, Jianmin Xu
Abstract
The present study demonstrated that APOL3 promotes ferroptosis and immunotherapy in colorectal cancer cells. The present work provides us with a novel target to overcome drug resistance to ferroptosis and immunotherapy.
Topics & Concepts
CD8Cancer researchImmunotherapyColorectal cancerCytotoxic T cellImmune systemTumor microenvironmentCancer immunotherapyBiologyT cellCancer cellCancerImmunologyIn vitroBiochemistryGeneticsFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer