Variants in Bedaquiline-Candidate-Resistance Genes: Prevalence in Bedaquiline-Naive Patients, Effect on MIC, and Association with Mycobacterium tuberculosis Lineage
Emmanuel Rivière, Lennert Verboven, Anzaan Dippenaar, Sander N. Goossens, Elise De Vos, Elizabeth M. Streicher, Bart Cuypers, Kris Laukens, Fathia Ben Rached, Timothy C. Rodwell, Arnab Pain, Robin M. Warren, Tim H. Heupink, Annelies Van Rie
Abstract
= 0.0004). The prevalence of variants in bedaquiline-resistance genes in isolates from bedaquiline-naive patients is high, but very few (<2%) isolates were phenotypically resistant. We found an association between variants in bedaquiline resistance genes and Mycobacterium tuberculosis (sub)lineage, resulting in a lineage-dependent difference in bedaquiline phenotype. Future studies should investigate the impact of the presence of variants on bedaquiline-resistance acquisition and treatment outcome.
Topics & Concepts
BedaquilineTuberculosisLineage (genetic)Mycobacterium tuberculosisBiologyCandidate genePhenotypeMedicineGeneGeneticsPathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisAntibiotic Resistance in Bacteria