The biology of the tumor microenvironment in DLBCL: Targeting the “don’t eat me” signal
Daisuke Ennishi
Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma with biologically and clinically heterogeneous features. Recently, the tumor microenvironment of this disease has been recognized as an important biological aspect of tumor development and therapeutic targets. Recurrent genetic alterations play significant roles in immune recognition of lymphoma cells. In particular, novel genetic alterations promoting phagocytosis were identified, suggesting a potential therapeutic strategy targeting the “don’t eat me” signal.
Topics & Concepts
Tumor microenvironmentCancer researchComputational biologyMedicineBiologyTumor cellsImmune Cell Function and InteractionCAR-T cell therapy researchPhagocytosis and Immune Regulation