A novel maladaptive unfolded protein response as a mechanism for small bowel resection-induced liver injury
Allie E. Steinberger, Maria Tecos, Hannah M. Phelps, Deborah C. Rubin, Nicholas O. Davidson, Jun Guo, Brad W. Warner
2022American Journal of Physiology-Gastrointestinal and Liver Physiology12 citationsDOIOpen Access PDF
Abstract
The unfolded protein response (UPR) is a complex signaling cascade that converges upon C/EBP-homologous protein (CHOP). Under conditions of chronic cellular stress, the UPR shifts from homeostatic to proapoptotic leading to inflammation and cell death. Here, we provide evidence that small bowel resection-induced liver injury and fibrosis are mediated by a maladaptive hepatic UPR. Low-fat diet, TUDCA treatment, and ileocecal resection rescued the hepatic phenotype and reversed the UPR pattern.
Topics & Concepts
Unfolded protein responseCHOPEndoplasmic reticulumHomeostasisInflammationMedicineResectionCancer researchInternal medicineCell biologyBiologySurgeryEndoplasmic Reticulum Stress and DiseaseLiver Disease Diagnosis and TreatmentPancreatic function and diabetes