Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury
Aleksandra Stamenković, Kimberley A. O’Hara, David C. Nelson, Thane G. Maddaford, Andrea L. Edel, Graham Maddaford, Elena Dibrov, Mohamad‐Reza Aghanoori, Lorrie A. Kirshenbaum, Paul Fernyhough, Michel Aliani, Grant N. Pierce, Amir Ravandi
Abstract
Oxidized phosphatidylcholines (OxPC) generated during reperfusion injury are potent inducers of cardiomyocyte death. Our studies have shown that OxPCs exert this effect through a ferroptotic process that can be attenuated. A better understanding of the OxPC cell death pathway can prove a novel strategy for prevention of cell death during myocardial reperfusion injury.
Topics & Concepts
TUNEL assayMyocyteViability assayProgrammed cell deathApoptosisChemistryIschemiaFura-2Mitochondrial permeability transition poreReperfusion injuryEndocrinologyInternal medicineMedicineBiochemistryCytosolEnzymeATP Synthase and ATPases ResearchFerroptosis and cancer prognosisTrace Elements in Health