Light-activated cytotoxicity of dicarbonyl Ru(<scp>ii</scp>) complexes with a benzimidazole coligand towards breast cancer
Nourhan Ibrahim, Rabaa M. Khaled, Mohamed A. Ragheb, Krzysztof Radacki, Ahmad M. Farag, Ahmed M. Mansour
Abstract
Upon photoinduced CO release, all the Ru( ii ) complexes acquired cytotoxicity against MCF-7 that may be attributed to the liberated CO and CO-depleted metal fragments including the liberated Coligands. Ru( ii ) complex of the unsubstituted ligand exhibited the highest activity.
Topics & Concepts
CytotoxicityChemistryBenzimidazoleRutheniumCarbon monoxideAmine gas treatingMedicinal chemistryStereochemistryPhotochemistryMetalMoleculeMetal carbonylPhotodissociationOrganic chemistryIn vitroCatalysisBiochemistryHeme Oxygenase-1 and Carbon MonoxideCO2 Reduction Techniques and CatalystsMetal-Catalyzed Oxygenation Mechanisms