Platelet-derived microvesicles induce calcium oscillations and promote VSMC migration <i>via</i> TRPV4
Shanshan Li, Shuang Gao, Yi Chen, Han Bao, Zi-Tong Li, Qing‐Ping Yao, Ji-Ting Liu, Yingxiao Wang, Ying‐Xin Qi
Abstract
TRPV4 participated in the calcium oscillations and VSMC migration induced by PMVs. PMVs and the related molecules might be novel therapeutic targets for vascular remodeling during vascular injury.
Topics & Concepts
MicrovesiclesPlateletCalciumCell biologyChemistryP2Y12TRPV4Platelet aggregationMedicineInternal medicineBiologyBiochemistryReceptormicroRNAIon channelGeneIon Channels and ReceptorsCardiovascular, Neuropeptides, and Oxidative Stress Research