Formulation and optimization of sildenafil citrate-loaded PLGA large porous microparticles using spray freeze-drying technique: A factorial design and in-vivo pharmacokinetic study
Hend I. Shahin, Bhavani Prasad Vinjamuri, Azza A. Mahmoud, Suzan M. Mansour, Mahavir B. Chougule, Lipika Chablani
Topics & Concepts
BioavailabilityPLGAFactorial experimentPharmacokineticsParticle sizeChemistrySildenafilPharmacologyOral administrationIn vivoChromatographyMedicineIn vitroBiochemistryInternal medicineMathematicsBiologyBiotechnologyStatisticsPhysical chemistryInhalation and Respiratory Drug DeliveryMicroencapsulation and Drying Processes