Mechanisms of IS <i>26</i> -Mediated Amplification of the <i>aphA1</i> Gene Leading to Tobramycin Resistance in an Acinetobacter baumannii Isolate
Christopher J. Harmer, François Lebreton, Jason Stam, Patrick McGann, Ruth M. Hall
Abstract
Heteroresistance, a significant issue that is known to impact antibiotic treatment outcomes, is caused by the presence of spontaneously arising cells with elevated levels of resistance to therapeutically important antibiotics in a population of susceptible cells. Gene amplification is one well-documented cause of heteroresistance, but precisely how extensive amplification occurs is not understood.
Topics & Concepts
TobramycinAcinetobacter baumanniiBiologyPlasmidTransposable elementGeneMicrobiologyGene duplicationKanamycinGeneticsAntibioticsGenomePseudomonas aeruginosaBacteriaGentamicinAntibiotic Resistance in BacteriaBacteriophages and microbial interactionsAdvanced biosensing and bioanalysis techniques