Photoredox-catalyzed halotrifluoromethylations of alkynes with triethylammonium halides: synthesis of tetrasubstituted alkenes containing CF<sub>3</sub> and halogens
Woori Lee, Yeonhee Lee, Minjin Yoo, Soo Bong Han, Hyun Jin Kim
Abstract
The introduction of F- and CF<sub>3</sub>-groups into alkynes is enabled by photocatalysis under mild conditions. The developed method can be extended to providing chloro- and bromotrifluoromethylated alkynes and bioactive compounds functionalization.
Topics & Concepts
ChemistryHalogenHalideCatalysisPhotocatalysisSurface modificationCombinatorial chemistryOrganic chemistryChlorineMedicinal chemistryAlkylPhysical chemistryFluorine in Organic ChemistryRadical Photochemical Reactions