Coexistence of Multidrug Resistance and Virulence in a Single Conjugative Plasmid from a Hypervirulent Klebsiella pneumoniae Isolate of Sequence Type 25
Peiwen Xia, Yi Miao, Yaling Yuan, Jinzhu Huang, Bingxue Yang, Jiajia Liao, Zijun Dang, Shengli Luo, Yun Xia
Abstract
The increased reporting of carbapenem-resistant hypervirulent K. pneumoniae is considered a worrisome concern to human health care and has restricted the choice of effective antibiotics for clinical treatment. Moreover, virulence plasmids with complete conjugation modules have been identified, which evolved via homologous recombination.
Topics & Concepts
AerobactinVirulencePlasmidKlebsiella pneumoniaeMicrobiologyBiologyMultiple drug resistanceAntibiotic resistanceDrug resistanceWhole genome sequencingVirologyEscherichia coliGeneEnterobacteriaceaeAntibioticsGeneticsGenomeAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyEnterobacteriaceae and Cronobacter Research