Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal
Lorena Hidalgo San Jose, Mary Jean Sunshine, Christopher H. Dillingham, Bernadette A. Chua, Miriama Krutá, Yuning Hong, Danny M. Hatters, Robert Signer
Abstract
HSCs. Thus, HSCs are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Topics & Concepts
HaematopoiesisStem cellProteomeHematopoietic stem cellCell biologyBiologyComputational biologyBioinformaticsHematopoietic Stem Cell TransplantationImmune Cell Function and InteractionAutophagy in Disease and Therapy