Porous starch microspheres loaded with luteolin exhibit hypoglycemic activities and alter gut microbial communities in type 2 diabetes mellitus mice
Xiaodong Ge, Tingting Liu, Yaolin Wang, Huanhuan Wen, Zirui Huang, Ligen Chen, Jianda Xu, Hongcheng Zhou, Qin Wu, Chao Zhao, Rong Shao, Wei Xu
Abstract
were identified as key intestinal marker genera involved in T2DM progression through Spearman correlation analysis. In conclusion, PS enhanced LUT's hypoglycemic efficacy by modulating the transcription and protein expression levels of AKT-1 and GLUT-2, as well as the relative abundance of potential gut pathogens in T2DM mice. These results provide a theoretical foundation for advancing luteolin's application in the functional food industry and further investigating its hypoglycemic potential.
Topics & Concepts
Diabetes mellitusType 2 Diabetes MellitusMicrosphereEndocrinologyStarchInternal medicineType 2 diabetesChemistryFood scienceMicrobiologyMedicineBiologyChemical engineeringEngineeringGut microbiota and healthFood composition and propertiesProbiotics and Fermented Foods