Construction of GSH-triggered cationic fluoropolymers as two-in-one nanoplatforms for combined chemo-gene therapy
Yu-Rong Zhan, Juan Tan, Meng-Wei Hei, Shiyong Zhang, Ji Zhang, Xiao‐Qi Yu
Abstract
anti-tumor assays both demonstrated that the co-delivery system could inhibit tumor growth more effectively than individual gene or drug therapy. Histopathological analysis of major organs indicated negligible systemic toxicity of such synergistic therapy systems. This rationally designed co-delivery vector provides an effective platform for the development of gene-drug synergistic therapy.
Topics & Concepts
Cationic polymerizationFluoropolymerGlutathioneDrug deliveryDrugGenetic enhancementGene deliveryNanotechnologyPharmacologyGeneMaterials scienceChemistryMedicineBiochemistryOrganic chemistryPolymerEnzymeRNA Interference and Gene DeliveryGraphene and Nanomaterials ApplicationsCancer Research and Treatments