Design, synthesis and biological evaluation of indanone–chalcone hybrids as potent and selective hCES2A inhibitors
Peng-Chao Huo, Xiao‐Qing Guan, Peng Liu, Yun‐Qing Song, Mengru Sun, Rong-Jing He, Li‐Wei Zou, Xue Li-juan, Jinhui Shi, Nan Zhang, Zhiguo Liu, Guang‐Bo Ge
Topics & Concepts
ChalconeChemistryCarboxylesteraseBiochemistryEnzyme inhibitorGrowth inhibitionPharmacologyEnzymeStereochemistryIn vitroBiologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsEnzyme function and inhibition