Regioselective C3–H Alkylation of Imidazopyridines with Donor–Acceptor Cyclopropanes
Oguzhan Dalkilic, Ozge Turbedaroglu, Ferruh Lafzi, Haydar Kilic
Abstract
Alkylated imidazopyridines are crucial structures for medicinal chemistry. Here, an efficient method for the C3-H alkylation of imidazopyridines was devised. Under Lewis acid-catalyzed conditions, reactions of imidazopyridines with different donor-acceptor cyclopropanes were carried out. Finally, 1,3-bisfunctionalizaton of donor-acceptor cyclopropanes was performed. In addition, synthesized C3-alkylated imidazopyridines are amenable for diverse synthetic applications.
Topics & Concepts
AlkylationRegioselectivityLewis acids and basesAcceptorChemistryCatalysisOrganic chemistryCombinatorial chemistryPhysicsCondensed matter physicsCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions